Nicklas Raun Jacobsen

Publikationer
2019

Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure

Tidsskriftartikel

2019

Kulstofnanorørs fysisk-kemiske egenskaber forudsiger langvarig inflammation på mus

Tidsskriftartikel

2019

Nanomaterial grouping: Existing approaches and future recommendations [Epub ahead of print]

Tidsskriftartikel

2019

Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice [Epub ahead of print]

Tidsskriftartikel

2018

Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice

Tidsskriftartikel

2018

Toxicity of pristine and paint-embedded TiO nanomaterials

Tidsskriftartikel

2018

Corrigendum to "MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs" [Toxicol. Appl. Pharmacol., 284 (2015) 16-32]

Kommentar/debat

2018

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation

Tidsskriftartikel

2018

Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice

Tidsskriftartikel

2018

Radicals generated by nanoparticles in contact with liquid water using spin trapping and mass spectrometry

Konferenceabstrakt til konference

2018

Radicals generated by nanoparticles in contact with liquid water using spin trapping and mass spectrometry

Poster

2018

Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice

Konferenceabstrakt til konference

2017

Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO nanoparticles

Tidsskriftartikel

2017

Surface modification does not influence the genotoxic and inflammatory effects of TiO2 nanoparticles after pulmonary exposure by instillation in mice

Tidsskriftartikel

2017

Biodistribution of carbon nanotubes in animal models

Tidsskriftartikel

2017

Identification of gene transcription start sites and enhancers responding to pulmonary carbon nanotube exposure in vivo

Tidsskriftartikel

2017

Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice

Tidsskriftartikel

2017

Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide

Tidsskriftartikel

2017

Challenges on the toxicological predictions of engineered nanoparticles

Tidsskriftartikel

2017

Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes

Tidsskriftartikel

2017

Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice

Tidsskriftartikel

2017

Grouping of manufactured nanomaterials: Strategies within NANoREG and NanoReg2

Konferenceabstrakt til konference

2017

Morphological changes in mouse liver one year after intratracheal instillation to carbon nanotubes

Konferenceabstrakt til konference

2017

Radicals generated by nanomaterials in contact with liquid water using spin trapping and mass spectrometry

Konferenceabstrakt til konference

2017

Readiness of control banding tools for safe innovation and regulatory occupational exposure assessment of nanomaterials

Konferenceabstrakt til konference

2017

Risk assessment analysis on candidate nanomaterials at different stages of the innovation change prior to Safe by Design-implementation. First results from Nanoeg2 H2020 project (WP2)

Konferenceabstrakt til konference

2017

Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice

Tidsskriftartikel

2017

Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles

Tidsskriftartikel

2017

Developmental toxicity of engineered nanomaterials

Bidrag til bog/antologi

2016

Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar-endothelial co-cultures

Tidsskriftartikel

2016

Kulstofnanorør påvirker lunger og blodbaner

Tidsskriftartikel

2016

Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials

Tidsskriftartikel

2016

A multilaboratory toxicological assessment of a panel of 10 engineered nanomaterials to human health-ENPRA Project - The highlights, limitations, and current and future challenges

Tidsskriftartikel

2016

No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro

Tidsskriftartikel

2016

Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

Tidsskriftartikel

2016

Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide

Tidsskriftartikel

2016

Åreforkalkning og funktionsforstyeelse af arterier efter udsættelse for forbrændingspartikler og nanopartikler

Tidsskriftartikel

2016

Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice

Tidsskriftartikel

2015

DNA damage following pulmonary exposure by instillation to low doses of carbon black (Printex 90) nanoparticles in mice

Tidsskriftartikel

2015

Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals

Tidsskriftartikel

2015

MWCNTs of different physicochemical properties causes similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

Tidsskriftartikel

2015

Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response

Tidsskriftartikel

2015

Time-dependent subcellular distribution and effects of carbon nanotubes in lungs of mice

Tidsskriftartikel

2015

Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease

Tidsskriftartikel

2015

DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice

Tidsskriftartikel

2015

Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice

Tidsskriftartikel

2015

Carbon black nanoparticles and other problematic constituents of black ink and their potential to harm tattooed humans

Tidsskriftartikel

2015

Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

Tidsskriftartikel

2015

Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories

Tidsskriftartikel

2015

Kroppens reaktion på lungeeksponering for forskellige typer af kulstofnanorør - et studie i mus

Tidsskriftartikel

2015

Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation

Tidsskriftartikel

2015

Carbon nanotubes. Types, products, market, and provisional assessment of the associated risks to man and the environment

Rapport

2014

Indånding af nanomaterialer øger risikoen for hjertekarsygdom

Tidsskriftartikel

2014

FIB-SEM imaging of carbon nanotubes in mouse lung tissue

Tidsskriftartikel

2014

Vascular effects of multiwalled carbon nanotubes in dyslipidemic ApoE-/- mice and cultured endothelial cells

Tidsskriftartikel

2014

Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

Tidsskriftartikel

2014

Role of oxidative stress in carbon nanotube-generated health effects

Tidsskriftartikel

2014

Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

Tidsskriftartikel

2014

Nanoparticles, carbon nanotubes and risk for lung cancer

Konferenceabstrakt til konference

2013

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

Tidsskriftartikel

2013

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

Tidsskriftartikel

2013

Øger indånding af (nano)partikler risikoen for hjerte-kar-sygdom?

Tidsskriftartikel

2013

Black tattoo inks induce reactive oxygen species production correlating with aggregation of pigment nanoparticles and product brand but not with the polycyclic aromatic hydrocarbon content

Tidsskriftartikel

2013

Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk

Tidsskriftartikel

2013

Bioaccumulation and ecotoxicity of carbon nanotubes

Tidsskriftartikel

2013

Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay

Tidsskriftartikel

2013

Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells

Tidsskriftartikel

2013

Carbon black nanoparticle intratracheal instillation does not alter cardiac gene expression

Tidsskriftartikel

2013

Akutfaserespons i lungerne - en mulig mekanisk forklaring på partikelforårsaget hjerte-kar-sygdom

Tidsskriftartikel

2012

Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers

Tidsskriftartikel

2012

Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

Tidsskriftartikel

2012

Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and laquers

Tidsskriftartikel

2012

Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver

Tidsskriftartikel

2012

Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint

Tidsskriftartikel

2012

"NANOKEM" - nanopartikler i farve og lakindustrien - eksponering og toksiske effekter

Tidsskriftartikel

2012

Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis

Tidsskriftartikel

2012

Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung

Tidsskriftartikel

2012

Mutationsspektrum: Mod en bedre forståelse af Printex 90 genotoksiske virkningsmekanismer

Konferenceabstrakt til konference

2011

Mutation spectrum in FE1-mutaTM mouse lung epithelial cells exposed to nanoparticulate carbon black

Tidsskriftartikel

2011

Nanopartikler i arbejdsmiljøet - stor ståhej for ingenting eller tid til rettidig omhu?

Tidsskriftartikel

2011

Mutagenicity of carbon nanomaterials

Tidsskriftartikel

2011

Nanopartikler i arbejdsmiljøet - stor ståhej for ingenting eller tid til rettidig omhu?

Tidsskriftartikel

2011

Nanopartikler i arbejdsmiljøet - stor ståhej for ingenting eller tid til rettidig omhu?

Tidsskriftartikel

2011

Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

Tidsskriftartikel

2011

Genotoxicity of nanoparticles in vivo

Konferenceabstrakt til konference

2011

Deliverable 2: Standard operating procedures for characterization of the selected manufactured nanomaterials types

Rapport

2011

Deliverable 3: Final protocol for producing suitable manufactured NM exposure media

Rapport

2010

Role of oxidative damage in toxicity of particulates

Tidsskriftartikel

2010

Genotoxicity of unmodified and organo-modified montmorillonite

Tidsskriftartikel

2010

Oxidative stress, inflammation and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter

Tidsskriftartikel

2010

Pulmonary exposure to carbon black nanoparticles and vascular effects

Tidsskriftartikel

2010

Preliminary risk evaluation of nano-(organo)-clay powders in the production of polymer nanocomposites. Part of nanoplast

Konferenceabstrakt til konference

2010

In vitro and in vivo toxicity of nanoclays [organo-modified montmorillonite)

Konferenceabstrakt til konference

2009

Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

Tidsskriftartikel

2009

Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes

Tidsskriftartikel

2009

Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis

Tidsskriftartikel

2009

Små rør med store muligheder

Tidsskriftartikel

2009

Investigation of release of QACs from nanoclays using in vitro extraction and LC-MS/MS

Konferenceabstrakt til konference

2009

Investigation of release of QACs from nanoclays using ASE extraction and LC-MS/MS

Poster

2009

Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation

Tidsskriftartikel

2009

Toxicity of carbon nanotubes: Research at the National Research Centre for the Working Environment

Konferenceabstrakt til konference

2009

In vitro toxicity of carbon nanotubes and naoclays )organoclays) used in plastic composite materials

Konferenceabstrakt til konference

2009

Safety of carbon nanotubes: A Danish Perspective

Konferenceabstrakt til konference

2008

Genotoxicity, cytotoxicity and reactive oxygen species induced by single-walled carbon nanotubes and C60 fullerenes in the FE1-MutaTMMouse lung epithelial cells

Tidsskriftartikel

2008

Små rør med store muligheder

Tidsskriftartikel

2008

Diesel exhaust particles are mutagenic in FE1-MutaTM mouse lung epithelial cells

Tidsskriftartikel

2008

Hazard assessment of engineered nanoparticles

Konferenceabstrakt til konference

2008

Mutagenicity, genotoxicity and inflammation caused by nanoparticles

Ph.d.-afhandling

2008

Nanotoxicology and nanosafety

Konferenceabstrakt til konference

2008

Risk assessment of engineered nanoparticles: The particle risk project

Konferenceabstrakt til konference

2007

Genotoxicity, inflammation and physico-chemical properties of fine particle samples from an incineration energy plant and urban air

Tidsskriftartikel

2007

Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta(trade mark)mouse lung epithelial cells

Tidsskriftartikel

2007

Carbon nanoparticle-induced formation of reactive oxygen species

Konferenceabstrakt til konference

2007

Detection and quantification of reactive oxygen species generated in nanoparticle aqueous suspensions and in human lung cell exposures

Konferenceabstrakt til konference

2006

Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor

Tidsskriftartikel

2004

Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer

Tidsskriftartikel

2004

XRCC3 polymorphisms and risk of lung cancer

Tidsskriftartikel

2003

No association between OGGI Ser326Cys polymorphism and breast cancer risk

Tidsskriftartikel

2003

No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer

Tidsskriftartikel

2003

Genetiske variationer i gener, der er involveret i oxidativt stress som risikofaktor for brystkræft

Tidsskriftartikel

2002

Multiple single nucleotide polymorphisms on human chromosome 19q13.2-3 associate with risk of basal cell carcinoma

Tidsskriftartikel

2002

Association of chromosome 19q13.2-3 haplotypes with basal cell carcinoma: tentative delineation of an involved region using data for single nucleotide polymorphisms in two cohorts

Tidsskriftartikel