Dansk Center for Nanosikkerhed

Afsluttet - Projektperiode 01. maj 2016 til 31. august 2019
Dansk Center for Nanosikkerhed forsker i sikker anvendelse af nanomaterialer på danske arbejdspladser.
Formål
Hovedformålet med Dansk Center for Nanosikkerhed er at bidrage med detaljeret viden om, hvordan udsættelse for teknisk fremstillede (producerede) nanomaterialer samt procesgenerede nanopartikler (også kaldet ultrafine partikler) påvirker arbejderes helbred.

Nanocentrets forskning bidrager til
• alle led i en risikovurdering af nanopartikler - deres karakterisering, måling og modellering af udsættelser samt undersøgelser af toksiske egenskaber af indåndede nanomaterialer.
• udviklingen af modeller, der gør det muligt at forudse de toksiske egenskaber af nye typer af nanomaterialer og anvise veje til safer-by-design baseret på deres fysisk-kemiske egenskaber og viden om grundlæggende toksikologiske virkningsmekanismer.

Derudover vil centret også udvikle et værktøj til risikohåndtering, der bl.a. kan forudsige effektiviteten af personlige værnemidler og ventilation.

Nanocenterets har særligt fokus på måling af niveauer for arbejderes udsættelse for partikler på virksomheder, der fremstiller eller anvender nanomaterialer i produktionen samt på at udvikle koncepter for, hvordan man skal kvantificere udsættelse for nanomaterialer. Derudover bidrager nanocenteret med viden om tekniske foranstaltninger og værnemidler, der mindsker udsættelsen.

Dansk Center for Nanosikkerhed bidrager også på Danmarks vegne til internationale aktiviteter i forhold til koordinering af forskning og regulering på nanoområdet, både i EU-régi og via EU-US koordineringsarbejde.

Nanocentret stiller sin viden til rådighed for alle dele af arbejdsmiljøsystemet, herunder Arbejdstilsynet, Miljøstyrelsen, arbejdsmarkedets parter og andre arbejdsmiljøprofessionelle.

Baggrund
Nanomaterialer bliver anvendt på danske arbejdspladser, og de kan udgøre et alvorligt arbejdsmiljøproblem. Forsøg med dyremodeller har nemlig vist, at nogle nanomaterialer er farligere at indånde end større partikler med den samme kemiske sammensætning. Det betyder blandt andet, at erhvervsmæssig udsættelse for nanomaterialer kan øge risikoen for at udvikle kræft og hjertekarsygdom.

En af de store udfordringer er, at arbejdspladserne ikke altid er klar over, at de anvender nanomaterialer. Sikkerhedsdatabladene for de pulvere, som arbejdspladserne anvender, kan nemlig mangle præcise oplysninger om indholdet af nanopartikler. Derfor kan det være svært for virksomhederne at vide, om de håndterer nanomaterialer. Arbejdspladsmålinger har vist, at der håndteres nanomaterialer på danske arbejdspladser, og at niveauerne er høje nok til at udgøre et potentielt helbredsproblem.

Det viser resultaterne af den forskning, som Dansk Center for Nanosikkerhed I udførte i perioden 1. maj 2012 til udgangen af april 2016.

I slutningen af 2015 bevilgede Folketinget penge til, at Dansk Center for Nanosikkerhed II kunne fortsætte forskningen i sikker anvendelse af nanomaterialer på danske arbejdspladser.

Mål
Målet med det arbejde, som Dansk Center for Nanosikkerhed udfører, er at sikre, at danske arbejdspladser har tilstrækkelig og velunderbygget viden til rådighed til at skabe et sikkert og sundt arbejdsmiljø for ansatte, der håndterer nanomaterialer i arbejdsmiljøet.

Nanocentrets hjemmeside
På nanocentrets hjemmeside www.nanosikkerhed.dk kan man blandt andet læse mere om centrets aktiviteter, læse nyheder om centrets forskningsresultater, se eller gense temamøder om nanosikkerhed og finde links til videnskabelige artikler om resultaterne af centrets forskning.

Projektleder og kontaktperson hos NFA

Ulla Birgitte Vogel

Ulla Birgitte Vogel

Professor

3916 5227

ubv@nfa.dk

Gå til profil
Resultater
  • Tidsskriftartikel (118)
    Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles
    Biodistribution of carbon nanotubes in animal models
    Challenges on the toxicological predictions of engineered nanoparticles
    Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes
    Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice
    Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice
    Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis
    Fibrillar vs crystalline nanocellulose pulmonary epithelial cell responses: Cytotoxicity or inflammation?
    Kulstofnanorørs fysisk-kemiske egenskaber og deres effekt på akutfaseresponset i blodet efter eksonering
    Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: Insights from an adverse outcome pathway framework
    Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk
    Positive staining for cellulose in oral pulse granuloma
    Quantitative material releases from products and articles containing manufactured nanomaterials: Towards a release library
    Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods
    Comparative, collaborative, and integrative risk governance for emerging technologies
    Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice
    Safety assessment of graphene-based materials: Focus on human health and the environment
    Toxicity of pristine and paint-embedded TiO nanomaterials
    BIOBRAND: Brandfolks eksponering ved brandslukning og biomarkører for risiko for kræft og hjerte-kar-sygdom
    NanoTI02 (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
    Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure
    Daily sperm production: application in studies of prenatal exposure to nanoparticles in mice
    Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation
    Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice
    Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk
    In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells
    Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay
    Black tattoo inks induce reactive oxygen species production correlating with aggregation of pigment nanoparticles and product brand but not with the polycyclic aromatic hydrocarbon content
    Carbon black nanoparticle intratracheal instillation does not alter cardiac gene expression
    Exposure assessment of four pharmaceutical powders based on dustiness and evaluation of damaged HEPA filters
    Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells
    NanoRiskCat: a conceptual tool for categorization and communication of exposure potentials and hazards of nanomaterials in consumer products
    FIB-SEM imaging of carbon nanotubes in mouse lung tissue
    Pulmonary toxicity following exposure to a tile coating product containing alkylsiloxanes. A clinical and toxicological evaluation
    Comparison of dust release from epoxy and paint nanocomposites and conventional products during sanding and sawing
    Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease
    DNA damage following pulmonary exposure by instillation to low doses of carbon black (Printex 90) nanoparticles in mice
    Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals
    Role of oxidative stress in carbon nanotube-generated health effects
    Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats
    Testing the near field/far field model performance for prediction of particulate matter emissions in a paint factory
    Characterization of exposure to carbon nanotubes in an industrial setting
    Range-finding risk assessment of inhalation exposure to nanodiamonds in a laboratory environment
    Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response
    Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice
    MWCNTs of different physicochemical properties causes similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs
    DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice
    High throughput sample processing and automated scoring
    Worker exposure and high time-resolution analyses of process-related submicrometre particle concentrations at mixing stations in two paint factories
    Interactions between nanoparticles and lung surfactant investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Workplace performance of a loose-fitting powered air purifying respirator during nanoparticle synthesis
    Exposure to airborne particles and volatile organic compounds from polyurethane molding, spray painting, lacquering, and gluing in a workshop
    A perspective on the developmental toxicity of inhaled nanoparticles
    Exposure assessment of particulate matter from abrasive treatment of carbon and glass fibre-reinforced epoxy-composites - Two case studies
    Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice
    Limitations in the use of unipolar charging for electrical mobility sizing instruments: A study of the fast mobility particle sizer
    An in vitro method for predicting inhalation toxicity of impregnation spray products
    Reproductive and developmental toxicity of carbon-based nanomaterials: A literature review
    Visualization of nanofibrillar cellulose in biological tissues using a biotinylated carbohydrate binding module of beta-1,4-glycanase
    Vascular effects of multiwalled carbon nanotubes in dyslipidemic ApoE-/- mice and cultured endothelial cells
    Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories
    Size-resolved characterization of particles and fibers released during abrasion of fiber-reinforced composite in a workplace influenced by ambient background sources
    Influence of relative humidity and physical load during storage on dustiness of inorganic nanomaterials: implications for testing and risk assessment
    Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar-endothelial co-cultures
    Carbon black nanoparticles and other problematic constituents of black ink and their potential to harm tattooed humans
    Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation
    Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers
    Can we trust real time measurements of lung deposited surface area concentrations in dust from powder nanomaterials?
    In vitro and in vivo genotoxic effects of straight versus tangled multi-walled carbon nanotubes
    Nano-risk Science: Application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes
    Control banding tools for occupational exposure assessment of nanomaterials - Ready for use in a regulatory context?
    Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity
    Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials
    Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials
    Airway irritation, inflammation and toxicity in mice following inhalation of metal oxide nanoparticles
    Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition
    Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs
    Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide
    Surface modification does not influence the genotoxic and inflammatory effects of TiO2 nanoparticles after pulmonary exposure by instillation in mice
    Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice
    Effects of developmental exposure to silver in ionic and nanoparticle form: A study in rats
    Inhalation and oropharyngeal aspiration exposure to rod-like carbon nanotubes induce similar airway inflammation and biological responses in mouse lungs
    Impact of fatty acid coating on the CCN activity of sea salt particles
    Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice
    Identification of gene transcription start sites and enhancers responding to pulmonary carbon nanotube exposure in vivo
    Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice
    Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises
    An efficient algorithm scheme for implementing the TEMOM for resolving aerosol dynamics
    Cardiovascular health effects following exposure of human volunteers during fire extinction exercises
    Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice
    Pulmonary exposure to carbonaceous nanomaterials and sperm quality
    Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift
    Comparison of geometrical layouts for a multi-box aerosol model from a single-chamber dispersion study
    In vivo-induced size transformation of cerium oxide nanoparticles in both lung and liver does not affect long-term hepatic accumulation following pulmonary exposure
    Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring
    Relating aerosol mass spectra to composition and nanostructure of soot particles
    Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice
    The effect of sampling inlet direction and distance on particle source measurements for dispersion modelling
    Source specific exposure and risk assessment for indoor aerosols
    Exposure to air pollution inside electric and diesel-powered passenger trains
    Ranking of nanomaterial potency to induce pathway perturbations associated with lung responses
    Health effects of exposure to diesel exhaust in diesel-powered trains
    Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    Improving the foundation for particulate matter risk assessment by individual nanoparticle statistics from electron microscopy analysis
    Particles influence allergic responses in mice-role of gender and particle size
    Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line
    Lessons learned from research on air pollution and other particles in the toxicology of nanomaterials and vice versa
    Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease
    Nanomaterials vs ambient ultrafine particles: An opportunity to exchange toxicology knowledge
    Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes
    Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice
    Association between a urinary biomarker for exposure to PAH and blood level of the acute phase protein serum amyloid A in coke oven workers
    Fra forskning i nanomaterialer til forebyggelse på arbejdspladser
    Kulstofnanorørs fysisk-kemiske egenskaber forudsiger langvarig inflammation på mus
    Commentary: The chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation
    Sperm quality and airway exposure to carbon-based particles and nanomaterials
    Effects of physicochemical properties of TiO nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice [Epub ahead of print]
  • Konferenceabstrakt til konference (6)
    Fornyet fokus på kemisk arbejdsmiljø - gammel vin på nye flasker?
    Udfordringer og praksis ved introduktion af nanoteknologi på virksomheder
    Particle emissions during lab-scale metal oxide synthesis and handling
    Dustiness of nanomaterial in powder: outcomes of the prenormative research project carried out under the M461 European mandate
    Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice
    Health effects of inhaled nanomaterials
  • Bidrag til bog/antologi (9)
    Roadmap as perspectives, miletones and pilot projects
    Developmental toxicity of engineered nanomaterials
    Characterization of manufactured nanomaterials, dispersion, and exposure for toxicological testing
    Case study: paints and lacquers with silica nanoparticles
    Methods for testing dustiness
    Feasibility and challenges of human health risk assessment for engineered nanomaterials
    Engineered nanomaterials: Their physicochemical characteristics and how to measure them
    Fertility and embryotoxicity
    Fertility and pregnancy
  • Leder (1)
    Editorial: Dose-dependent ZnO particle-induced acute phase response in humans warrants re-evaluation of occupational exposure limits for metal oxides
  • Rapport (1)
    Arbejdsmiljømæssige udfordringer som følge af automatisering og digitalisering. En rapport om trends og tendenser med relevans for fremtidens arbejdsmarked
  • Konferenceabstrakt i tidsskrift (2)
    Effetcs of nanoparticles on male and female fertility
    Pathomorphological pattern of the mouse lungs and liver after repeated intratracheal instillation with different carbonaceous nanomaterials