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NFA’s forskning i kemisk arbejdsmiljø, toksikologi, nanosikkerhed og mikrobiologi

Formålet med dette forskningsområde er at afdække og kortlægge de væsentligste forekomster af kemiske og biologiske eksponeringer i arbejdsmiljøet i Danmark samt at undersøge, hvordan de påvirker lønmodtagernes helbred, og hvordan det kan forebygges. Der vil blive udviklet risikovurderingsredskaber og forebyggelsesinitiativer, som er tilpasset arbejdspladserne, samt etableret dokumentationsgrundlag for myndighedernes regulering af kemiske stoffer.

Kemisk arbejdsmiljø

Forskningen i kemisk arbejdsmiljø defineres bredt som udsættelse for naturligt forekommende og menneskeskabte kemiske stoffer og blandinger af disse og omfatter væsker, partikler, røg, damp og gasser i arbejdsmiljøet og deres påvirkning af helbredet.

Nanosikkerhed

Nanosikkerhedsforskningen, som sigter mod at udrede helbredsrisici ved udsættelse for partikler i nanostørrelse og ved nanomaterialer i arbejdsmiljøet, vil blive fortsat i regi af Dansk Center for Nanosikkerhed samt flere større EU-projekter med fokus på arbejdsmiljø og nanosikkerhed. 

I Nanosikkerhedscentret er der nu også fokus på ultrafine partikler, kortlægning af anvendelsen af nanopartikler i Danmark, arbejdspladsmålinger og afdækning af toksikologiske virkningsmekanismer, hvilket muliggør, at nanomaterialer kan klassificeres i forskellige risikogrupper.

Mikrobiologi

Den mikrobiologiske forskning vil fortsat arbejde med måling af eksponering, identifikation af danske arbejdsmiljøer med høj eksponering og mekanismer med betydning for helbredseffekter. En central opgave er at komme med anbefalinger til forebyggelse baseret på arbejdspladsmålinger af bioaerosoler. 

Yderligere oplysninger

Se strategi for Det Nationale Forskningscenter for Arbejdsmiljø

Toksikologidatabaser for arbejdsmiljøet
Internettet er den hurtige vej til info om giftige stoffer i arbejdsmiljøet - ofte gratis. Her kan du finde nogle af de bedste databaser på området.

Om projekter og udgivelser på nfa.dk

Alle projekter og udgivelser, der bliver vist på nfa.dk, ligger i systemet Pure. Vi arbejder fortsat på at få vist oplysningerne korrekt på hjemmesiden. Hvis I oplever problemer, eller der er noget I ikke kan finde, er I velkomne til at kontakte os. I kan finde kontaktoplysninger nederst på siden.

  • Allergi
    Tidsskriftsartikler
    2018
    Pig farmers' homes harbor more diverse airborne bacterial communities than pig stables or suburban homes
    2017
    Alterations of the murine gut microbiome in allergic airway disease are independent of surfactant protein D
    2017
    Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use
    2016
    Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers
    2016
    Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
    Se alle
  • Arbejdshygiejne
    Igangværende projekter
    2019
    Dansk Center for Nanosikkerhed
    2018
    Risiko for smitte med MRSA fra borger til personale i den primære sundhedssektor
    Se alle
    Afsluttede projekter
    2017
    Eksponering for mikroorganismer ved indsamling af papaffald - betyder det noget for arbejdsmiljøet, at drikkekartoner og pizzabakker udgør en del af papaffaldet?
    Se alle
    Tidsskriftsartikler
    2018
    Insulation fiber deposition in the airways of men and rats. A review of experimental and computational studies
    2018
    Dip coating of air purifier ceramic honeycombs with photocatalytic TiO2 nanoparticles
    2018
    Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model
    2018
    Occupational exposure during handling and loading of halloysite nanotubes – A case study of counting nanofibers
    2018
    Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods
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  • Epidemiologi
    Tidsskriftsartikler
    2018
    Impact of di-2-ethylhexyl phthalate metabolites on male reproductive function: A systematic review of human evidence
    2018
    Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis
    2018
    Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis
    2017
    Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use
    2017
    Association between single nucleotide polymorphisms in the antioxidant genes CAT, GR and SOD1, erythrocyte enzyme activities, dietary and life style factors and breast cancer risk in a Danish, prospective cohort study
    Se alle
  • Hjertekarsygdomme
    Tidsskriftsartikler
    2017
    Cardiovascular health effects following exposure of human volunteers during fire extinction exercises
    2017
    Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide
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  • Hudlidelser
    Tidsskriftsartikler
    2009
    Self-reported occupational skin contact with cleaning agents and the risk of disability pension
    2008
    Experiences with implementation of evidence-based prevention programs to prevent occupational skin diseases in different occupations
    2007
    Identification of subjects with atopic dermatitis in questionnaire studies
    2007
    Self-reported hand eczema in a hospital population
    2006
    A study of the implementation process of an intervention to prevent work-related skin problems in wet-work occupations
    Se alle
  • Indeklima
    Tidsskriftsartikler
    2018
    The general ventilation multipliers calculated by using a standard Near-Field/Far-Field model
    2018
    Comparison of geometrical layouts for a multi-box aerosol model from a single-chamber dispersion study
    2018
    Assessment of indoor air quality problems in office-like environments: Role of occupational Health services
    2018
    Indoor air humidity, air quality, and health - An overview
    2018
    Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model
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  • Kemisk arbejdsmiljoe
    Igangværende projekter
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS - Grouping, Read-Across, CharacterIsation and classificati On framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products
    2021
    PATROLS - Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment
    2020
    Inflammatory stress transfer between mother and fetus
    2019
    Fjerkræ og eksponering for mikroorganismer
    Se alle
    Tidsskriftsartikler
    2018
    Time scales of developmental toxicity impacting on research and needs for intervention {Epub ahead of print]
    2018
    Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer
    2018
    Airborne MRSA and total Staphylococcus aureus as associated with particles of different sizes on pig farms
    2018
    Sensory irritation of vapours of formic, acetic, propionic and butyric acid
    2018
    Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis
    Se alle
  • Kraeft
    Igangværende projekter
    2019
    Dansk Center for Nanosikkerhed
    Se alle
    Afsluttede projekter
    2013
    Udvikling af bæredygtige løsninger inden for nanoteknologibaserede produkter
    Se alle
    Tidsskriftsartikler
    2018
    Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis
    2018
    Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises
    2018
    GLTSCR1, ATM, PPP1R13L and CD3EAP genetic variants and lung cancer risk in a Chinese population
    2018
    Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study
    2018
    Occupational exposure during handling and loading of halloysite nanotubes – A case study of counting nanofibers
    Se alle
  • Luftvejslidelser
    Afsluttede projekter
    2016
    Lungesurfaktant funktion in vitro - imprægneringsprodukter
    Se alle
    Tidsskriftsartikler
    2018
    Bile salt enhancers for inhalation
    2016
    Limonene and its ozone-initiated reaction products attenuate allergic lung inflammation in mice
    2016
    Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
    Se alle
  • Metoder
    Afsluttede projekter
    2018
    CEN Dustiness
    Se alle
    Tidsskriftsartikler
    2016
    Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia
    Se alle
  • Mikrobiologi
    Igangværende projekter
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS - Grouping, Read-Across, CharacterIsation and classificati On framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products
    2021
    PATROLS - Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment
    2020
    Inflammatory stress transfer between mother and fetus
    2019
    Fjerkræ og eksponering for mikroorganismer
    Se alle
    Tidsskriftsartikler
    2018
    Time scales of developmental toxicity impacting on research and needs for intervention {Epub ahead of print]
    2018
    Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer
    2018
    Airborne MRSA and total Staphylococcus aureus as associated with particles of different sizes on pig farms
    2018
    Sensory irritation of vapours of formic, acetic, propionic and butyric acid
    2018
    Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis
    Se alle
  • Nanosikkerhed
    Igangværende projekter
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS - Grouping, Read-Across, CharacterIsation and classificati On framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products
    2021
    PATROLS - Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment
    2020
    Inflammatory stress transfer between mother and fetus
    2019
    Fjerkræ og eksponering for mikroorganismer
    Se alle
    Tidsskriftsartikler
    2018
    Time scales of developmental toxicity impacting on research and needs for intervention {Epub ahead of print]
    2018
    Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer
    2018
    Airborne MRSA and total Staphylococcus aureus as associated with particles of different sizes on pig farms
    2018
    Sensory irritation of vapours of formic, acetic, propionic and butyric acid
    2018
    Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis
    Se alle
  • Partikler
    Igangværende projekter
    2019
    caLIBRAte - test, kalibrering og implementering af et nyt model-baseret system til risikostyring under innovation og produktion af tekniske nanomaterialer
    Se alle
    Afsluttede projekter
    2018
    CEN Dustiness
    2010
    Nanopartikler i farve- og lakindustrien. Eksponering og toksiske egenskaber
    Se alle
    Tidsskriftsartikler
    2018
    Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer
    2018
    Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring
    2018
    Telomere shortening and aortic plaque progression in Apoliprotein E knockout mice after pulmonary exposure to candle light combustion particles
    2018
    Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice [Epub ahead of print]
    2018
    Comparative, collaborative, and integrative risk governance for emerging technologies
    Se alle
  • Toksikologi
    Igangværende projekter
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS - Grouping, Read-Across, CharacterIsation and classificati On framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products
    2021
    PATROLS - Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment
    2020
    Inflammatory stress transfer between mother and fetus
    2019
    Fjerkræ og eksponering for mikroorganismer
    Se alle
    Tidsskriftsartikler
    2018
    Time scales of developmental toxicity impacting on research and needs for intervention {Epub ahead of print]
    2018
    Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer
    2018
    Airborne MRSA and total Staphylococcus aureus as associated with particles of different sizes on pig farms
    2018
    Sensory irritation of vapours of formic, acetic, propionic and butyric acid
    2018
    Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis
    Se alle