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NFA’s forskning i kemisk arbejdsmiljø, toksikologi, nanosikkerhed og mikrobiologi

Formålet med dette forskningsområde er at afdække og kortlægge de væsentligste forekomster af kemiske og biologiske eksponeringer i arbejdsmiljøet i Danmark samt at undersøge, hvordan de påvirker lønmodtagernes helbred, og hvordan det kan forebygges. Der vil blive udviklet risikovurderingsredskaber og forebyggelsesinitiativer, som er tilpasset arbejdspladserne, samt etableret dokumentationsgrundlag for myndighedernes regulering af kemiske stoffer.

kemi

Kemisk arbejdsmiljø

Forskningen i kemisk arbejdsmiljø defineres bredt som udsættelse for naturligt forekommende og menneskeskabte kemiske stoffer og blandinger af disse og omfatter væsker, partikler, røg, damp og gasser i arbejdsmiljøet og deres påvirkning af helbredet.

Nanosikkerhed

Nanosikkerhedsforskningen, som sigter mod at udrede helbredsrisici ved udsættelse for partikler i nanostørrelse og ved nanomaterialer i arbejdsmiljøet, vil blive fortsat i regi af Dansk Center for Nanosikkerhed samt flere større EU-projekter med fokus på arbejdsmiljø og nanosikkerhed.

I Nanosikkerhedscentret er der nu også fokus på ultrafine partikler, kortlægning af anvendelsen af nanopartikler i Danmark, arbejdspladsmålinger og afdækning af toksikologiske virkningsmekanismer, hvilket muliggør, at nanomaterialer kan klassificeres i forskellige risikogrupper.

Mikrobiologi

Den mikrobiologiske forskning vil fortsat arbejde med måling af eksponering, identifikation af danske arbejdsmiljøer med høj eksponering og mekanismer med betydning for helbredseffekter. En central opgave er at komme med anbefalinger til forebyggelse baseret på arbejdspladsmålinger af bioaerosoler.

Yderligere oplysninger

Se strategi for Det Nationale Forskningscenter for Arbejdsmiljø

Toksikologidatabaser for arbejdsmiljøet Internettet er den hurtige vej til info om giftige stoffer i arbejdsmiljøet - ofte gratis. Her kan du finde nogle af de bedste databaser på området.
  • Allergi
    Tidsskriftsartikler
    2018
    Pig farmers' homes harbor more diverse airborne bacterial communities than pig stables or suburban homes
    2017
    Alterations of the murine gut microbiome in allergic airway disease are independent of surfactant protein D
    2017
    Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use
    2016
    Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers
    2016
    Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
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  • Arbejdshygiejne
    Igangværende projekter
    2021
    Fjerkræ og eksponering for mikroorganismer
    2020
    SmartNanoTox - Smart Tools for Gauging Nano Hazards
    2019
    Dansk Center for Nanosikkerhed
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    Afsluttede projekter
    2018
    Erhvervsmæssig eksponering for MRSA blandt social- og sundhedsassistenter
    2018
    Risiko for smitte med MRSA fra borger til personale i den primære sundhedssektor
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    Tidsskriftsartikler
    2019
    Measurement of dust-borne MRSA in pig farms using different approaches
    2019
    Improving the foundation for particulate matter risk assessment by individual nanoparticle statistics from electron microscopy analysis
    2019
    Microbial species and biodiversity in settling dust within and between pig farms
    2019
    Occupational exposure during treatment of offshore drilling waste and characterization of microbiological diversity
    2018
    Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives
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  • Epidemiologi
    Igangværende projekter
    2021
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    Tidsskriftsartikler
    2018
    Impact of di-2-ethylhexyl phthalate metabolites on male reproductive function: A systematic review of human evidence
    2018
    Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy
    2018
    Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis
    2018
    Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis
    2017
    Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use
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  • Hjertekarsygdomme
    Igangværende projekter
    2020
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    Tidsskriftsartikler
    2019
    FADS and PPARG2 single nucleotide polymorphisms are associated with plasma lipids in 9-mo-old infants
    2017
    Cardiovascular health effects following exposure of human volunteers during fire extinction exercises
    2017
    Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide
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  • Hudlidelser
    Tidsskriftsartikler
    2012
    Hand eczema: Prevalence and risk factors of hand eczema in a population of 2274 healthcare workers
    2009
    Self-reported occupational skin contact with cleaning agents and the risk of disability pension
    2008
    Experiences with implementation of evidence-based prevention programs to prevent occupational skin diseases in different occupations
    2007
    Identification of subjects with atopic dermatitis in questionnaire studies
    2007
    Self-reported hand eczema in a hospital population
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  • Indeklima
    Afsluttede projekter
    2017
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    Tidsskriftsartikler
    2019
    Source specific exposure and risk assessment for indoor aerosols
    2018
    The mystery of dry indoor air - An overview
    2018
    The general ventilation multipliers calculated by using a standard Near-Field/Far-Field model
    2018
    Comparison of geometrical layouts for a multi-box aerosol model from a single-chamber dispersion study
    2018
    Assessment of indoor air quality problems in office-like environments: Role of occupational Health services
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  • Kemisk arbejdsmiljø
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
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    2021
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    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS
    Se alle
    Tidsskriftsartikler
    2019
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    2019
    Health effects of exposure to diesel exhaust in diesel-powered trains
    2019
    Parallel sequencing of porA reveals a complex pattern of Campylobacter genotypes that differs between broiler and broiler breeder chickens
    2019
    Exposure to air pollution inside electric and diesel-powered passenger trains
    2019
    Health risk assessment from exposure to particles during packing in working environments
    Se alle
  • Kræft
    Igangværende projekter
    2020
    SmartNanoTox - Smart Tools for Gauging Nano Hazards
    2019
    NanoPack (EU) WP 6
    2019
    Dansk Center for Nanosikkerhed
    Se alle
    Afsluttede projekter
    2013
    Udvikling af bæredygtige løsninger inden for nanoteknologibaserede produkter - NanoSustain
    Se alle
    Tidsskriftsartikler
    2018
    Safety assessment of graphene-based materials: Focus on human health and the environment
    2018
    Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month
    2018
    Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis
    2018
    Association between polycyclic aromatic hydrocarbon exposure and peripheral blood mononuclear cell DNA damage in human volunteers during fire extinction exercises
    2018
    GLTSCR1, ATM, PPP1R13L and CD3EAP genetic variants and lung cancer risk in a Chinese population
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  • Luftvejslidelser
    Igangværende projekter
    2021
    Sprayprodukter, kemiske stoffer og astma i rengøringsbranchen
    2020
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    Se alle
    Afsluttede projekter
    2018
    In vitro metoder for at screene effekten af per- og polyfluoralkyl stoffer på lungerne
    2016
    Lungesurfaktant funktion in vitro - imprægneringsprodukter
    Se alle
    Tidsskriftsartikler
    2019
    Health risk assessment from exposure to particles during packing in working environments
    2018
    Safety assessment of graphene-based materials: Focus on human health and the environment
    2018
    Bile salt enhancers for inhalation: Correlation between in vitro and in vivo lung effects
    2018
    Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month
    2016
    Limonene and its ozone-initiated reaction products attenuate allergic lung inflammation in mice
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  • Metoder
    Afsluttede projekter
    2018
    DUSTINANO – Nanomaterialers støvning
    Se alle
    Tidsskriftsartikler
    2019
    Improving the foundation for particulate matter risk assessment by individual nanoparticle statistics from electron microscopy analysis
    2019
    Interaction of biologically relevant proteins with ZnO nanomaterials: A confounding factor for in vitro toxicity endpoints
    2016
    Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia
    Se alle
  • Mikrobiologi
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2021
    Doc-X generation - en national fødselskohorte
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS
    Se alle
    Tidsskriftsartikler
    2019
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    2019
    Health effects of exposure to diesel exhaust in diesel-powered trains
    2019
    Parallel sequencing of porA reveals a complex pattern of Campylobacter genotypes that differs between broiler and broiler breeder chickens
    2019
    Exposure to air pollution inside electric and diesel-powered passenger trains
    2019
    Health risk assessment from exposure to particles during packing in working environments
    Se alle
  • Nanosikkerhed
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2021
    Doc-X generation - en national fødselskohorte
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS
    Se alle
    Tidsskriftsartikler
    2019
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    2019
    Health effects of exposure to diesel exhaust in diesel-powered trains
    2019
    Parallel sequencing of porA reveals a complex pattern of Campylobacter genotypes that differs between broiler and broiler breeder chickens
    2019
    Exposure to air pollution inside electric and diesel-powered passenger trains
    2019
    Health risk assessment from exposure to particles during packing in working environments
    Se alle
  • Partikler
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2020
    Hvordan kommer inflammation fra mor til foster?
    2020
    SmartNanoTox - Smart Tools for Gauging Nano Hazards
    2019
    NanoPack (EU) WP 6
    Se alle
    Tidsskriftsartikler
    2019
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    2019
    Health effects of exposure to diesel exhaust in diesel-powered trains
    2019
    Exposure to air pollution inside electric and diesel-powered passenger trains
    2019
    Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice
    2019
    Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice
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  • Reproduktionsskader
    Igangværende projekter
    2021
    Doc-X generation - en national fødselskohorte
    2020
    Hvordan kommer inflammation fra mor til foster?
    Se alle
    Afsluttede projekter
    2018
    Med mor på Job
    2010
    Arvelige mutationer efter prænatal udsættelse for nanopartikler
    2010
    Stress i fostertilstanden som risikofaktor for psykiske lidelser
    Se alle
    Tidsskriftsartikler
    2019
    Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice
    2018
    Time scales of developmental toxicity impacting on research and needs for intervention [Epub ahead of print]
    2018
    Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring
    2017
    Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner
    2017
    Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice
    Se alle
  • Toksikologi
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2021
    Doc-X generation - en national fødselskohorte
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    2021
    GRACIOUS
    Se alle
    Tidsskriftsartikler
    2019
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    2019
    Health effects of exposure to diesel exhaust in diesel-powered trains
    2019
    Parallel sequencing of porA reveals a complex pattern of Campylobacter genotypes that differs between broiler and broiler breeder chickens
    2019
    Exposure to air pollution inside electric and diesel-powered passenger trains
    2019
    Health risk assessment from exposure to particles during packing in working environments
    Se alle
  • Værktøjer
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    Se alle
    Tidsskriftsartikler
    2018
    Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives
    Se alle