NFA’s forskning i kemisk arbejdsmiljø, toksikologi, nanosikkerhed og mikrobiologi

Formålet med dette forskningsområde er at afdække og kortlægge de væsentligste forekomster af kemiske og biologiske eksponeringer i arbejdsmiljøet i Danmark samt at undersøge, hvordan de påvirker lønmodtagernes helbred, og hvordan det kan forebygges. Der vil blive udviklet risikovurderingsredskaber og forebyggelsesinitiativer, som er tilpasset arbejdspladserne, samt etableret dokumentationsgrundlag for myndighedernes regulering af kemiske stoffer.

kemi

Kemisk arbejdsmiljø

Forskningen i kemisk arbejdsmiljø defineres bredt som udsættelse for naturligt forekommende og menneskeskabte kemiske stoffer og blandinger af disse og omfatter væsker, partikler, røg, damp og gasser i arbejdsmiljøet og deres påvirkning af helbredet.

Nanosikkerhed

Nanosikkerhedsforskningen, som sigter mod at udrede helbredsrisici ved udsættelse for partikler i nanostørrelse og ved nanomaterialer i arbejdsmiljøet, vil blive fortsat i regi af Dansk Center for Nanosikkerhed samt flere større EU-projekter med fokus på arbejdsmiljø og nanosikkerhed.

I Nanosikkerhedscentret er der nu også fokus på ultrafine partikler, kortlægning af anvendelsen af nanopartikler i Danmark, arbejdspladsmålinger og afdækning af toksikologiske virkningsmekanismer, hvilket muliggør, at nanomaterialer kan klassificeres i forskellige risikogrupper.

Mikrobiologi

Den mikrobiologiske forskning vil fortsat arbejde med måling af eksponering, identifikation af danske arbejdsmiljøer med høj eksponering og mekanismer med betydning for helbredseffekter. En central opgave er at komme med anbefalinger til forebyggelse baseret på arbejdspladsmålinger af bioaerosoler.

Yderligere oplysninger

Se strategi for Det Nationale Forskningscenter for Arbejdsmiljø

Toksikologidatabaser for arbejdsmiljøet Internettet er den hurtige vej til info om giftige stoffer i arbejdsmiljøet - ofte gratis. Her kan du finde nogle af de bedste databaser på området.
  • Allergi
    Tidsskriftsartikler
    2018
    Pig farmers' homes harbor more diverse airborne bacterial communities than pig stables or suburban homes
    2017
    Alterations of the murine gut microbiome in allergic airway disease are independent of surfactant protein D
    2017
    Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use
    2016
    Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers
    2016
    Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
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  • Arbejdshygiejne
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    2023
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    Afsluttede projekter
    2019
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    2018
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    Tidsskriftsartikler
    2019
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    2019
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    2019
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    2019
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    2018
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    2021
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    Tidsskriftsartikler
    2019
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    2018
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    2018
    Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy
    2018
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    2018
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  • Hjertekarsygdomme
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    2020
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    Tidsskriftsartikler
    2019
    FADS and PPARG2 single nucleotide polymorphisms are associated with plasma lipids in 9-mo-old infants
    2017
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    2017
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  • Hudlidelser
    Tidsskriftsartikler
    2012
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    2009
    Self-reported occupational skin contact with cleaning agents and the risk of disability pension
    2008
    Experiences with implementation of evidence-based prevention programs to prevent occupational skin diseases in different occupations
    2007
    Identification of subjects with atopic dermatitis in questionnaire studies
    2007
    Self-reported hand eczema in a hospital population
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  • Indeklima
    Afsluttede projekter
    2017
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    Tidsskriftsartikler
    2019
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    2018
    The mystery of dry indoor air - An overview
    2018
    The general ventilation multipliers calculated by using a standard Near-Field/Far-Field model
    2018
    Comparison of geometrical layouts for a multi-box aerosol model from a single-chamber dispersion study
    2018
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  • Kemisk arbejdsmiljø
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    2023
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    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
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    2021
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    2021
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    Tidsskriftsartikler
    2019
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    2019
    Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study
    2019
    Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice [Epub ahead of print]
    2019
    Airway exposure to TiO nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice [Epub ahead of print]
    2019
    Nanomaterial grouping: Existing approaches and future recommendations [Epub ahead of print]
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  • Kræft
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    2020
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    2019
    NANOPACK – Forsøgsproduktion af nanobaseret antibakteriel emballage til fødevarer
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    Afsluttede projekter
    2019
    Dansk Center for Nanosikkerhed
    2013
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    Se alle
    Tidsskriftsartikler
    2019
    Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study
    2019
    No interaction between polymorphisms related to vitamin A metabolism and vitamin A intake in relation to colorectal cancer in a prospective Danish cohort
    2018
    Safety assessment of graphene-based materials: Focus on human health and the environment
    2018
    Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month
    2018
    Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis
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  • Luftvejslidelser
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    2021
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    2020
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    Afsluttede projekter
    2018
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    2016
    Lungesurfaktant funktion in vitro - imprægneringsprodukter
    Se alle
    Tidsskriftsartikler
    2019
    Health risk assessment from exposure to particles during packing in working environments
    2018
    Safety assessment of graphene-based materials: Focus on human health and the environment
    2018
    Bile salt enhancers for inhalation: Correlation between in vitro and in vivo lung effects
    2018
    Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month
    2016
    Limonene and its ozone-initiated reaction products attenuate allergic lung inflammation in mice
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  • Metoder
    Afsluttede projekter
    2018
    DUSTINANO – Nanomaterialers støvning
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    Tidsskriftsartikler
    2019
    Data supporting the investigation of interaction of biologically relevant proteins with ZnO nanomaterials: A confounding factor for in vitro toxicity endpoints
    2019
    Improving the foundation for particulate matter risk assessment by individual nanoparticle statistics from electron microscopy analysis
    2019
    Interaction of biologically relevant proteins with ZnO nanomaterials: A confounding factor for in vitro toxicity endpoints
    2016
    Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia
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  • Mikrobiologi
    Igangværende projekter
    2023
    NanoInformaTIX – Udvikling og implementering af en modelleringsplatform indeholdende nanoinformatik
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2021
    Doc-X generation - en national fødselskohorte
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    Se alle
    Tidsskriftsartikler
    2019
    Indoor dispersion of airborne nano and fine particles: Main factors affecting spatial and temporal distribution in the frame of exposure modeling
    2019
    Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study
    2019
    Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice [Epub ahead of print]
    2019
    Airway exposure to TiO nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice [Epub ahead of print]
    2019
    Nanomaterial grouping: Existing approaches and future recommendations [Epub ahead of print]
    Se alle
  • Nanosikkerhed
    Igangværende projekter
    2023
    NanoInformaTIX – Udvikling og implementering af en modelleringsplatform indeholdende nanoinformatik
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2021
    Doc-X generation - en national fødselskohorte
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    Se alle
    Tidsskriftsartikler
    2019
    Indoor dispersion of airborne nano and fine particles: Main factors affecting spatial and temporal distribution in the frame of exposure modeling
    2019
    Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study
    2019
    Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice [Epub ahead of print]
    2019
    Airway exposure to TiO nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice [Epub ahead of print]
    2019
    Nanomaterial grouping: Existing approaches and future recommendations [Epub ahead of print]
    Se alle
  • Partikler
    Igangværende projekter
    2023
    NanoInformaTIX – Udvikling og implementering af en modelleringsplatform indeholdende nanoinformatik
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2020
    Hvordan kommer inflammation fra mor til foster?
    2020
    SmartNanoTox
    Se alle
    Tidsskriftsartikler
    2019
    Nanomaterial grouping: Existing approaches and future recommendations [Epub ahead of print]
    2019
    Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
    2019
    Health effects of exposure to diesel exhaust in diesel-powered trains
    2019
    Exposure to air pollution inside electric and diesel-powered passenger trains
    2019
    Data supporting the investigation of interaction of biologically relevant proteins with ZnO nanomaterials: A confounding factor for in vitro toxicity endpoints
    Se alle
  • Reproduktionsskader
    Igangværende projekter
    2021
    Doc-X generation - en national fødselskohorte
    2020
    Hvordan kommer inflammation fra mor til foster?
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    Afsluttede projekter
    2018
    Med mor på Job
    2010
    Arvelige mutationer efter prænatal udsættelse for nanopartikler
    2010
    Stress i fostertilstanden som risikofaktor for psykiske lidelser
    Se alle
    Tidsskriftsartikler
    2019
    Airway exposure to TiO nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice [Epub ahead of print]
    2019
    Time scales of developmental toxicity impacting on research and needs for intervention
    2019
    The influence of multiple occupational exposures on absence from work in pregnancy: A prospective cohort study [Epub ahead of print]
    2019
    Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice
    2018
    Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring
    Se alle
  • Toksikologi
    Igangværende projekter
    2023
    NanoInformaTIX – Udvikling og implementering af en modelleringsplatform indeholdende nanoinformatik
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    2022
    GOV4NANO
    2021
    Doc-X generation - en national fødselskohorte
    2021
    HBM4EU – Human biomonitering skal sikre sikker håndtering af kemikalier i EU
    Se alle
    Tidsskriftsartikler
    2019
    Indoor dispersion of airborne nano and fine particles: Main factors affecting spatial and temporal distribution in the frame of exposure modeling
    2019
    Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study
    2019
    Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice [Epub ahead of print]
    2019
    Airway exposure to TiO nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice [Epub ahead of print]
    2019
    Nanomaterial grouping: Existing approaches and future recommendations [Epub ahead of print]
    Se alle
  • Værktøjer
    Igangværende projekter
    2023
    NANOsolveIT: Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology
    Se alle
    Tidsskriftsartikler
    2018
    Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives
    Se alle