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Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Tidsskriftartikel - 2017


BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.

METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.

RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.

CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.


Dudele A, Hougaard KS, Kjølby M, Hokland M, Winther G, Elfving B, Wegener G, Nielsen AL, Larsen A, Nøhr MK, Pedersen SB, Wang T, Lund S. Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity 2017;41(9):1420-1426.
doi: 10.1038/ijo.2017.136

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