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Study protocol: effort-reward imbalance at work and risk of type 2 diabetes - a prospective study linking survey and register data

Udgivelser på nettet - Net-publikation - 2018

Resume

Background: Diabetes is a growing public health concern. Psychosocial factors at work might be associated with an increased risk of developing type 2 diabetes. One hypothesised mechanism is stress stimulated cortisol release via the HPA-axis, where cortisol is involved in blood glucose regulation. High levels of blood glucose lead to secretion of insulin to the blood and if this continues, insulin resistance might develop, which is associated with the development of type 2 diabetes. Other possible pathways might be via associations of psychosocial work factors with 1) adverse health-related behaviour such as physical inactivity, and 2) psycho-physiological disturbances associated with overweight and metabolic changes. However, the current research on the relationship between psychosocial work factors and type 2 diabetes is inconclusive.

Objective: This protocol describes the planned analyses for a study aiming to investigate the prospective association of effort-reward imbalance at work and its sub-dimensions with the risk of developing type 2 diabetes.

Methods: The population under study is a sample of workers in Denmark from the biennial survey “Work Environment and Health in Denmark 2012-2020”. We include approximately 50,000 participants aged 30-64 years. The participants are linked to and followed in national registers. We will apply Cox proportional hazards models to study the prospective association of effort-reward imbalance with risk of type 2 diabetes with adjustment for a range of demographic and social determinants.

Discussion: We expect that this study will expand the current knowledge about the potential impact of psychosocial work factors on the risk of developing type 2 diabetes.

Reference

Study protocol: effort-reward imbalance at work and risk of type 2 diabetes - a prospective study linking survey and register data. 2018.
doi: https://doi.org/10.6084/m9.figshare.6809363.v1

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Psykosocialt arbejdsmiljø, diabetes, sygefravær og førtidspension i den danske arbejdsstyrke (PSA-DISPO)