Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells

Tidsskriftartikel - 2013

Resume

[Open access] There is great interest in substituting animal work with in vitro experimentation in human health risk assessment; however, there are only few comparisons of in vitro and in vivo biological responses to engineered nanomaterials. We used high-content genomics tools to compare in vivo pulmonary responses of multiwalled carbon nanotubes (MWCNT) to those in vitro in cultured lung epithelial cells (FE1) at the global transcriptomic level. Primary size, surface area and other properties of M

Reference

Poulsen SS, Jacobsen NR, Labib S, Wu D, Husain M, Williams A, Bøgelund J, Andersen O, Kobler C, Mølhave K, Kyjovska Z, Saber AT, Wallin EHR, Yauk C, Vogel UB, Halappanavar S. Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells. PLoS One 2013;8(11):e80452-.
doi: 10.1371/journal.pone.0080452

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Dansk Center for Nanosikkerhed