Animal testing for acute inhalation toxicity: A thing of the past?

Tidsskriftartikel - 2018

Resume

According to REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), testing for acute inhalation toxicity is required for chemicals manufactured or imported at tonnages?≥?10 tons per year. Three OECD test guidelines for acute inhalation toxicity in vivo are adopted (TG 403, TG 436, and TG 433). Since animal testing is ethically, scientifically and economically questionable, adoption of alternative methods by the European Union and the OECD is needed. An in vitro system based on the study of lung surfactant function is introduced.

Reference

Da Silva E, Sørli JB. Animal testing for acute inhalation toxicity: A thing of the past?. Applied In Vitro Toxicology 2018;4(2):89-90.
doi: 10.1089/aivt.2017.0037

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