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Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise

Tidsskriftartikel - 2005

Resume

Interleukin-6 (IL-6), which is released from muscle tissue during intense exercise, possesses important metabolic and probably anti-inflammatory properties. To evaluate the IL-6 response to low-intensity exercise we conducted two studies: I) a control study with insertion of microdialysis catheters in muscle and determination of interstitial muscle IL-6 response over two hours of rest and II) an exercise study to investigate the IL-6 response to 20 min repetitive low-force exercise. In both studies a microdialysis catheter (cut-off 3000 kDa) was inserted into the upper trapezius muscle of 6 male subjects and the catheters were perfused with ringer-acetat at 5 µl min-1. Venous plasma samples were taken in the exercise study. The insertion of microdialysis catheters into muscle resulted in an increase in IL-6 from 8 ± 0 pg ml-1 to 359 ± 171 and 484 ± 202 pg ml-1 after 65 and 110 min, respectively (P

Reference

Rosendal L, Søgaard K, Kjær M, Sjøgaard G, Langberg H, Kristiansen J. Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. J Appl Physiol 2005;98(2):477-481.
doi: doi:10.1152/japplphysiol.00130.2004

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