Nicklas Raun Jacobsen

Acute phase response as a biological mechanism-of-action of (nano)particle-Induced cardiovascular disease

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Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure

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Kulstofnanorørs fysisk-kemiske egenskaber forudsiger langvarig inflammation på mus

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Nanomaterial grouping: Existing approaches and future recommendations

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Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice

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Fra forskning i nanomaterialer til forebyggelse på arbejdspladser

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Commentary: The chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation

Kommentar/debat

Effects of physicochemical properties of TiO nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice [Epub ahead of print]

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Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks [Epub ahead of print]

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Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice

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Toxicity of pristine and paint-embedded TiO nanomaterials

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Corrigendum to "MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs" [Toxicol. Appl. Pharmacol., 284 (2015) 16-32]

Kommentar/debat

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation

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Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice

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Radicals generated by nanoparticles in contact with liquid water using spin trapping and mass spectrometry

Konferenceabstrakt til konference

Radicals generated by nanoparticles in contact with liquid water using spin trapping and mass spectrometry

Poster

Physicochemical predictors of multi-walled carbon nanotube-induced pulmonary histopathology and toxicity one year after pulmonary deposition of 11 different multi-walled carbon nanotubes in mice

Konferenceabstrakt til konference

Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO nanoparticles

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Surface modification does not influence the genotoxic and inflammatory effects of TiO2 nanoparticles after pulmonary exposure by instillation in mice

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Biodistribution of carbon nanotubes in animal models

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Identification of gene transcription start sites and enhancers responding to pulmonary carbon nanotube exposure in vivo

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Hepatic hazard assessment of silver nanoparticle exposure in healthy and chronically alcohol fed mice

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Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide

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Challenges on the toxicological predictions of engineered nanoparticles

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Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes

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Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice

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Grouping of manufactured nanomaterials: Strategies within NANoREG and NanoReg2

Konferenceabstrakt til konference

Morphological changes in mouse liver one year after intratracheal instillation to carbon nanotubes

Konferenceabstrakt til konference

Radicals generated by nanomaterials in contact with liquid water using spin trapping and mass spectrometry

Konferenceabstrakt til konference

Readiness of control banding tools for safe innovation and regulatory occupational exposure assessment of nanomaterials

Konferenceabstrakt til konference

Risk assessment analysis on candidate nanomaterials at different stages of the innovation change prior to Safe by Design-implementation. First results from Nanoeg2 H2020 project (WP2)

Konferenceabstrakt til konference

Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice

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Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles

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Developmental toxicity of engineered nanomaterials

Bidrag til bog/antologi

Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar-endothelial co-cultures

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Kulstofnanorør påvirker lunger og blodbaner

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Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials

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A multilaboratory toxicological assessment of a panel of 10 engineered nanomaterials to human health-ENPRA Project - The highlights, limitations, and current and future challenges

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No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro

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Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

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Inflammation and vascular effects after repeated intratracheal instillations of carbon black and lipopolysaccharide

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Åreforkalkning og funktionsforstyeelse af arterier efter udsættelse for forbrændingspartikler og nanopartikler

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Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice

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DNA damage following pulmonary exposure by instillation to low doses of carbon black (Printex 90) nanoparticles in mice

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Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals

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MWCNTs of different physicochemical properties causes similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

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Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response

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Time-dependent subcellular distribution and effects of carbon nanotubes in lungs of mice

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Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease

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DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice

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Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice

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Carbon black nanoparticles and other problematic constituents of black ink and their potential to harm tattooed humans

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Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

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Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories

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Kroppens reaktion på lungeeksponering for forskellige typer af kulstofnanorør - et studie i mus

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Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation

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Carbon nanotubes. Types, products, market, and provisional assessment of the associated risks to man and the environment

Rapport

Indånding af nanomaterialer øger risikoen for hjertekarsygdom

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FIB-SEM imaging of carbon nanotubes in mouse lung tissue

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Vascular effects of multiwalled carbon nanotubes in dyslipidemic ApoE-/- mice and cultured endothelial cells

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Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

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Role of oxidative stress in carbon nanotube-generated health effects

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Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

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Nanoparticles, carbon nanotubes and risk for lung cancer

Konferenceabstrakt til konference

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

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Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

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Øger indånding af (nano)partikler risikoen for hjerte-kar-sygdom?

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Black tattoo inks induce reactive oxygen species production correlating with aggregation of pigment nanoparticles and product brand but not with the polycyclic aromatic hydrocarbon content

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Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk

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Bioaccumulation and ecotoxicity of carbon nanotubes

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Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay

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Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells

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Carbon black nanoparticle intratracheal instillation does not alter cardiac gene expression

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Akutfaserespons i lungerne - en mulig mekanisk forklaring på partikelforårsaget hjerte-kar-sygdom

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Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers

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Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

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Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and laquers

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Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver

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Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint

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"NANOKEM" - nanopartikler i farve og lakindustrien - eksponering og toksiske effekter

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Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis

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Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung

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Mutationsspektrum: Mod en bedre forståelse af Printex 90 genotoksiske virkningsmekanismer

Konferenceabstrakt til konference

Mutation spectrum in FE1-mutaTM mouse lung epithelial cells exposed to nanoparticulate carbon black

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Nanopartikler i arbejdsmiljøet - stor ståhej for ingenting eller tid til rettidig omhu?

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Mutagenicity of carbon nanomaterials

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Nanopartikler i arbejdsmiljøet - stor ståhej for ingenting eller tid til rettidig omhu?

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Nanopartikler i arbejdsmiljøet - stor ståhej for ingenting eller tid til rettidig omhu?

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Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2

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Genotoxicity of nanoparticles in vivo

Konferenceabstrakt til konference

Deliverable 2: Standard operating procedures for characterization of the selected manufactured nanomaterials types

Rapport

Deliverable 3: Final protocol for producing suitable manufactured NM exposure media

Rapport

Role of oxidative damage in toxicity of particulates

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Genotoxicity of unmodified and organo-modified montmorillonite

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Oxidative stress, inflammation and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter

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Pulmonary exposure to carbon black nanoparticles and vascular effects

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Preliminary risk evaluation of nano-(organo)-clay powders in the production of polymer nanocomposites. Part of nanoplast

Konferenceabstrakt til konference

In vitro and in vivo toxicity of nanoclays [organo-modified montmorillonite)

Konferenceabstrakt til konference

Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

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Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes

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Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis

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Små rør med store muligheder

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Investigation of release of QACs from nanoclays using in vitro extraction and LC-MS/MS

Konferenceabstrakt til konference

Investigation of release of QACs from nanoclays using ASE extraction and LC-MS/MS

Poster

Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation

Tidsskriftartikel

Toxicity of carbon nanotubes: Research at the National Research Centre for the Working Environment

Konferenceabstrakt til konference

In vitro toxicity of carbon nanotubes and naoclays )organoclays) used in plastic composite materials

Konferenceabstrakt til konference

Safety of carbon nanotubes: A Danish Perspective

Konferenceabstrakt til konference

Genotoxicity, cytotoxicity and reactive oxygen species induced by single-walled carbon nanotubes and C60 fullerenes in the FE1-MutaTMMouse lung epithelial cells

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Små rør med store muligheder

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Diesel exhaust particles are mutagenic in FE1-MutaTM mouse lung epithelial cells

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Hazard assessment of engineered nanoparticles

Konferenceabstrakt til konference

Mutagenicity, genotoxicity and inflammation caused by nanoparticles

Ph.d.-afhandling

Nanotoxicology and nanosafety

Konferenceabstrakt til konference

Risk assessment of engineered nanoparticles: The particle risk project

Konferenceabstrakt til konference

Genotoxicity, inflammation and physico-chemical properties of fine particle samples from an incineration energy plant and urban air

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Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta(trade mark)mouse lung epithelial cells

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Carbon nanoparticle-induced formation of reactive oxygen species

Konferenceabstrakt til konference

Detection and quantification of reactive oxygen species generated in nanoparticle aqueous suspensions and in human lung cell exposures

Konferenceabstrakt til konference

Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor

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Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer

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XRCC3 polymorphisms and risk of lung cancer

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No association between OGGI Ser326Cys polymorphism and breast cancer risk

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No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer

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Genetiske variationer i gener, der er involveret i oxidativt stress som risikofaktor for brystkræft

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Multiple single nucleotide polymorphisms on human chromosome 19q13.2-3 associate with risk of basal cell carcinoma

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Association of chromosome 19q13.2-3 haplotypes with basal cell carcinoma: tentative delineation of an involved region using data for single nucleotide polymorphisms in two cohorts

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